pntd.0008287.s002.pdf (103.32 kB)
Specific inhibition of rCsFBPase and native CsFBPase by MB05032.
journal contribution
posted on 2020-04-30, 17:56 authored by Shan Li, Xueqing Chen, Juanjuan Zhou, Zhizhi Xie, Mei Shang, Lei He, Pei Liang, Tingjin Chen, Qiang Mao, Chi Liang, Xuerong Li, Yan Huang, Xinbing Yu(A) Percent inhibition of rCsFBPase by 0–50 mM AMP or 0–500 μM MB05032. (B) Percent inhibition of native CsFBPase in soluble protein of adult flukes by 0–50 mM AMP or 0–500 μM MB05032. (C) Inhibition of rCsFBPase and rCsFbA-2 by 10 μM MB05032. The 50% inhibiting concentration (IC50) of AMP (positive control) and MB05032 against rCsFBPase or native CsFBPase were calculated using four-parameter logistics nonlinear regression, respectively. The activities of rCsFBPase or rCsFbA-2 with or without the addition of MB05032 were compared by student’s t test. **P < 0.01 was represented as statistical significance; n.s., not significant.
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