pone.0203860.g001.tif (247.66 kB)
Simulated dataset.
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posted on 2018-09-25, 17:31 authored by Flora Alarcon, Violaine Planté-Bordeneuve, Malin Olsson, Grégory NuelReference and estimation of the survival function S(t) for carriers with 95% point-wise confidence intervals (dashed lines). A total of n = 3,285 (1,641 males and 1,644 females) individuals including 441 affected and 319 genotyped. Left: simulation and estimation without gender effect. Right: simulation and estimation with a proportional protective effect for females (gender = 2).
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EMsurvival functionWeibull survivalBayesian networksfamily sampleshazard modelfactors effectsprevention strategiessurvival procedurespedigrees datamutation carriersKaplan-Meier non-parametric estimatesmutation carriers managementmutation carrier survival estimatessurvival function estimationrisk assessmentNon-parametric estimation
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