Simulated dataset.

Reference and estimation of the survival function S(t) for carriers with 95% point-wise confidence intervals (dashed lines). A total of n = 3,285 (1,641 males and 1,644 females) individuals including 441 affected and 319 genotyped. Left: simulation and estimation without gender effect. Right: simulation and estimation with a proportional protective effect for females (gender = 2).