Significantly regulated genes, Gene Ontologies and Canonical Pathways observed in hippocampal tissues from mTBI, mTBI/PHEN and PHEN animals are presented.
Red arrows indicate up regulated genes, Green arrows indicate down regulated genes. A: Genes: by 14 days after injury, 50 and 129 genes were commonly up and down regulated, respectively, in the three treatment groups. The largest numbers of genes exclusively regulated were observed in the mTBI+PHEN treated animals, 332 genes and 528 genes were exclusively up and down regulated, respectively. Due to the large numbers of genes the identities and Z-ratios of the genes are provided in S1 Table. B: Gene ontologies: ontologies derived from altered genes in hippocampal tissues indicate that 20 and 22 gene ontologies were commonly up and down regulated, respectively, in the three treatment groups. Several CNS or neuronal gene ontology listings are described in the results section; however, all ontology identities and Z-scores are provided in S2 Table. C: Pathways: molecular pathways derived from altered genes in hippocampal tissues indicate no pathways were commonly regulated in the three treatment groups. Several pathways were CNS- or neuronal-related. These pathways are described in the results section. A list of pathways with corresponding Z-scores is provided in S3 Table.