Fig 9.tif (1.02 MB)
Schematic figure illustrating the signaling pathway activation with mechanical ventilation.
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posted on 2017-02-24, 19:17 authored by Li-Fu Li, Chung-Shu Lee, Chang-Wei Lin, Ning-Hung Chen, Li-Pang Chuang, Chen-Yiu Hung, Yung-Yang LiuBleomycin-induced augmentation of mechanical stretch-mediated cytokine production and EMT were attenuated by the administration of trichostatin A and with Akt heterozygous knockout. Akt+/- = Akt-deficient mice; EMT = epithelial-mesenchymal transition; HDAC = histone deacetylase; MMP-9 = matrix metalloproteinase-9; PAI-1 = plasminogen activator inhibitor-1; TSA = trichostatin A.
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HDAC 4staininglung injuryventilator-induced lung injuryplasminogen activator inhibitorhigh-V T MVHDAC 4 expressionMV-augmented lung inflammationAkt-deficient C 57BL miceTSA treatment attenuates high-V T MV-augmented EMTALIMMPAkt activationMV-augmented bleomycin-induced EMTattenuates ventilation-augmented epithelial-mesenchymal transitionAkt pathway Background Mechanical ventilation1 gene expressionARDSmatrix metalloproteinase -9Akt pathways
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