Representative histological findings of myocardial tissue evaluation at 35th day post-infarction after long-term oral treatment (6th– 35th day) with captopril (2 × 25 mg/kg) or M-2 (4 mg/kg) (hematoxylin and eozine-stained).
(A) Intact specimen of sham-operated heart, (B-C) Control 0.9% NaCl, (D) DMSO group, (E-F) Captopril group, (G) M-2 group (scanned with 20× objective, bar represents 50–100 μm).
(A)
Closely arranged cardiomyocytes with comparable nuclei. Normal myocardial tissue (magnification 30×).
(B)
Non-uniform cardiomyocytes with enlarged, rounded nuclei suggesting early cardiomyopathic process. Interstitial space contains some lymphocytes (magnification 30×).
(C)
Evident cardiomyopathic pattern with perivascular inflammatory infiltrations composed of lymphocytes and larger macrophages (magnification 30×).
(D)
Myocardial tissue morphology resembles intact group specimens (magnification 30×).
(E)
Typical cardiomyopathic pattern with numerous, dense inflammatory infiltrations with evident histiocytes, lymphocytes and other cells (magnification 30×).
(F)
Advanced cardiomyopathy with present fibrotic focai (magnification 20×).
(G)
Moderate cardiomyopathic pattern with lesser inflammatory infiltrations in comparison to captopril group. Regular fibrotic process (magnification 20×).
Closely arranged cardiomyocytes with comparable nuclei. Normal myocardial tissue (magnification 30×).
Non-uniform cardiomyocytes with enlarged, rounded nuclei suggesting early cardiomyopathic process. Interstitial space contains some lymphocytes (magnification 30×).
Evident cardiomyopathic pattern with perivascular inflammatory infiltrations composed of lymphocytes and larger macrophages (magnification 30×).
Myocardial tissue morphology resembles intact group specimens (magnification 30×).
Typical cardiomyopathic pattern with numerous, dense inflammatory infiltrations with evident histiocytes, lymphocytes and other cells (magnification 30×).
Advanced cardiomyopathy with present fibrotic focai (magnification 20×).
Moderate cardiomyopathic pattern with lesser inflammatory infiltrations in comparison to captopril group. Regular fibrotic process (magnification 20×).
