Replicate populations with higher mutation rates have increased genetic diversity and more high frequency derived alleles.

<p>Each circle represents (A) the distance of a population to its center (vertical axis), (B) the number of sites with derived alleles at a frequency exceeding 50% (vertical axis), or (C) the mean nucleotide site diversity (vertical axis) in an evolving replicate population over the course of the evolution experiment (horizontal axes). Different colors distinguish data from the MR<sup>S</sup> (blue), MR<sup>M</sup> (yellow), MR<sup>L</sup> (orange), and MR<sup>XL</sup> (red) strains.</p>