pone.0210656.g002.tif (2.64 MB)
Renal inflammatory cytokine determinations in mice with AAI-induced acute nephropathy.
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posted on 2019-01-11, 18:36 authored by Wen-Yeh Hsieh, Teng-Hsiang Chang, Hui-Fang Chang, Wan-Hsuan Chuang, Li-Che Lu, Chung-Wei Yang, Chih-Sheng Lin, Chia-Chu ChangChanges in renal IL-6 (A), TGF-β1 (B) and TNF-α (C) levels were determined. All values are expressed as the means ± SD from each group (n = 9). ** indicates p < 0.01 compared to the Control group; † and †† indicate p < 0.05 and p < 0.01 compared to the AAI group, respectively.
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ACEIangiotensin II formationp-Smad 3 levelsBWAng II levelAAI-induced nephropathy progressionAng II levelskidney injury developmentchymase hydrates AngRenal chymase-dependent pathwayACEaristolochic acid I-inducedCIAng IInephropathy Angiotensin-converting enzymeC 57BL miceAAI-treated miceroleAAI-induced nephropathic miceRenal RAS-related enzyme activities
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