RNA-seq profiling of PC9 cells after PRAME knockdown.

(A) RNA-seq analysis of 3 samples of PC9 cell transfected with PRAME siRNA and control siRNA. Heatmap represents the differentially expressed genes after the knockdown of PRAME. Each column represents one sample, and each row refers to one gene. Top-left is the color legend with the green color indicating the upregulated genes. (B) GO analysis of the differentially expressed genes for the cellular function characterization of these genes. (C) List of the top 65 genes significantly altered after the knockdown of PRAME, which are closely related to cell migration.