ppat.1008079.g008.tif (1.15 MB)
Proposed molecular mechanism for the function of p200 family proteins (IFI204) to inhibit IRF7-mediated activation of type I IFNs responses.
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posted on 2019-10-11, 17:32 authored by Liu Cao, Yanxi Ji, Lanyi Zeng, Qianyun Liu, Zhen Zhang, Shuting Guo, Xiaolong Guo, Yongjia Tong, Xiaolu Zhao, Chun-Mei Li, Yu Chen, Deyin GuoSchematic diagram demonstrates the mechanism of p200 family proteins to suppress type I IFNs responses. Late after RNA virus infection, the highly expressed p200 family proteins, such as IFI204, interact with IRF7 in the nucleus and such interactions lead to the negative regulation of type I IFNs responses.
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P 200 family protein IFI 204IRF 7mouse hepatitis coronavirus-infected bone marrow-derived dendritic cellsHIN domaininterferon responseinterferon-inducible p 200 family proteinsnucleus Interferon-inducible p 200 family protein IFI 204IRF 7-mediated typeRNA virus infectionDNA virus infectionIFI 204p 200 family proteins
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