ppat.1008124.g010.tif (1.01 MB)
Proposed model of how P. gingivalis gingipains send bacterial virulence factors through the gingival epithelium.
figure
posted on 2019-11-07, 18:59 authored by Hiroki Takeuchi, Naoko Sasaki, Shunsuke Yamaga, Masae Kuboniwa, Michiya Matsusaki, Atsuo AmanoP. gingivalis gingipains degrade JAM1, which increases the permeability of gingival epithelium to gingipains and other factors. Subsequently, gingipains are transferred to the deeper epithelium to further degrade JAM1, which allows LPS and PGN to penetrate the gingival epithelium and reach subepithelial tissues. Finally, gingipains, LPS, and PGN induce inflammation in gingival tissues.
History
Usage metrics
Categories
Keywords
Lys-specific cysteine proteasesGingival epithelial cellsLPSdegradationJAM 1 homodimers40 kDa dextrangingipaingingival epithelial interfacegingival epithelial cellsJAM 1. KnockdownJAM 1PGNjunctional adhesion moleculejunctional adhesion molecule 1 Porphyromonas gingivalisgingival epitheliumepithelial barrier function
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC