Principal component analysis (PCA) of wild-type BDNF and its variant V66M.

The plots are showing the first two principal components (PC1 and PC2) extracted from the essential dynamics. The trajectory frames for wild-type BDNF and its variant V66M were colored from blue to red according to time evolution. (A) PCA plot of wild-type BDNF. The first two PCs account for 59.24% of the total structural variance. (B) PCA plot of variant V66M. The first two PCs account for 50.67% of the total structural variance. (C) PCA comparison between wild-type BDNF (black) and its variant V66M (blue).