Pressure-overload induced concentric hypertrophy and reactive fibrosis.

(Panel A) Left ventricular (LV) wall thickness, circumference, (Panel B) interstitial and perivascular fibrosis as determined by Masson Trichrome staining were significantly increased in suprarenal abdominal aorta constricted rats (SAC) versus sham rats. Analysis was performed on a subpopulation of SAC (n = 3) and sham (n = 4) rats and (*) denotes p<0.05 versus sham as determined by a student’s unpaired t-test.