pone.0210656.g003.tif (7.06 MB)
Pathological features of AAI-induced kidney injury revealed by light microscopy.
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posted on 2019-01-11, 18:36 authored by Wen-Yeh Hsieh, Teng-Hsiang Chang, Hui-Fang Chang, Wan-Hsuan Chuang, Li-Che Lu, Chung-Wei Yang, Chih-Sheng Lin, Chia-Chu ChangThe upper panels show H&E staining and leukocyte infiltration indicative of the inflammation induced by AAI treatment and the alleviation of this response by ACEI, CI and the combination of ACEI and CI (ACEI + CI) treatments. The lower panels show PAS staining and the lesions of tubular atrophy induced by AAI treatment, and the alleviation of lesions by ACEI, CI and ACEI + CI treatments.
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ACEIangiotensin II formationp-Smad 3 levelsBWAng II levelAAI-induced nephropathy progressionAng II levelskidney injury developmentchymase hydrates AngRenal chymase-dependent pathwayACEaristolochic acid I-inducedCIAng IInephropathy Angiotensin-converting enzymeC 57BL miceAAI-treated miceroleAAI-induced nephropathic miceRenal RAS-related enzyme activities
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