OSU53 is more efficient than other known AMPK activators in protecting OB-6 cells against Dex.
OB-6 cells were pretreated with OSU53 (10 μM), A-769662 (“A7”, 10 μM) or Compound 13 (“C13”, 10 μM) for 1 hour, followed by Dex (1 μM) stimulation for 24 hours, cell viability (MTT assay) was shown (A). Experiments in this figure were repeated three times, and similar results were obtained. *p<0.05 vs. “Dex” only treatment. # p<0.05 vs. OSU53 treatment group.