Numerical simulations under different control strategies combined with two or three measures.

The left and right columns indicate chemotherapy targeted on whole population and at-risk population with raw-fish-consumption behaviors, respectively. The simulation of chemotherapy was once per year for five years. The black dotted lines indicate the observed baseline prevalence from survey data. The dash dot line indicates the transmission control prevalence (i.e., 1%). The solid lines indicate results based on best set of estimated parameters and the areas with lighter colors represent the corresponding 95% confidence intervals. (A1-A2) with coverage of chemotherapy C_m = 0.90, coverage of sanitation toilets C_d = 0 and improvement rate of both kinds of healthy behaviors C_e = 0.30, 0.60, 0.90 (red, green, blue, respectively); (B1-B2) with C_m = 0.90, C_e= 0 and C_d = 0.30, 0.60, 0.90 (red, green, blue, respectively); (C1-C2) with C_m = 0.90, C_e = C_d = 0.30, 0.60, 0.90 (red, green, blue, respectively); (D1-D2) with C_e = 0.90, C_d = 0 and C_m = 0.40, 0.60, 0.80 (red, green, blue, respectively); (E1-E2) with C_d = 0.90, C_e = 0 and C_m = 0.40, 0.60, 0.80 (red, green, blue, respectively); and (F1-F2) with C_e = C_d = 0.90 and C_m = 0.40, 0.60, 0.80 (red, green, blue, respectively).