Numerical simulations of the model of homologous PB regimes with different parameters values.

A). Behavior of effector T cells after prime according to Eq (1). PB protocols are defined by choosing nine boost timings equally distributed between the initiation of the T cell response and the end of clonal contraction. B) Memory T cells formed for PB protocols that differ in prime dose and boost time, using a high total antigen dose. C) As B with lower antigen load. Results are normalized relative to the maximum in each figure. Black planes show the minimum value of memory formation for comparison. D,E) Same as B and C for a different choice of parameter values. The values of the parameters used in these simulations are the following (in suitable units): (B) A0 = 20000, λA = 450, c = 40, k = 250, λH = 10, φ = 107, μ = 1, α = 15, β = 0.04 and Ea(0) = Ma(0) = 10. (C) Same as in B, with A0 = 200. (D) A0 = 10000, λP = 250, c = 50, k = 120, λH = 10, φ = 107, μ = 1, A0 = 107, μ = 1, α = 2, β = 0.2 and Ea(0) = Ma(0) = 10. (E) Same as in C, with A0 = 1000.