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Normal pups were obtained from Drc7 KO spermatozoa with ICSI.

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posted on 2020-01-21, 18:34 authored by Akane Morohoshi, Haruhiko Miyata, Keisuke Shimada, Kaori Nozawa, Takafumi Matsumura, Ryuji Yanase, Kogiku Shiba, Kazuo Inaba, Masahito Ikawa

(A) Development of ICSI embryos. Oocytes injected with Drc7 KO spermatozoa developed to the 2-cell stage and pups were obtained after embryo transfer. (B) Genotyping of obtained pups. Four pups were derived from Drc7 KO spermatozoa. (C) Pups derived from Drc7 KO spermatozoa.

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    PLOS Genetics

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    component DRC 7sperm flagellum formationFbxl 13microtubuleDrc 7 expressionNexin-Dynein Regulatory Complexunicellular flagellate ChlamydomonasTCTE 1FBXL 13Drc 7 KODrc 7 KO spermatidsN-DRCFbxl 13 knockout

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