Fig 6.TIF (1.79 MB)
Neuronal apoptosis in the brains of focal cerebral ischemia/reperfusion rats as shown by TUNEL assay.
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posted on 2016-10-21, 17:30 authored by Qian Lu, Jihong Wang, Junshu Jiang, Shengnan Wang, Qilan Jia, Yue Wang, Weiping Li, Qin Zhou, Li Lv, Qingwei LiA, B, C, D, E, and F represent the sham group, the VT group, the rLj-RGD3 100.0 μg·kg-1 group, the rLj-RGD3 50.0 μg·kg-1 group, the Edaravone 1.5 mg·kg-1 group, and the Eptifibatide 100.0 μg·kg-1 group, respectively. Neuronal apoptosis was not observed in the sham group. In contrast, a significant amount of neuronal apoptosis was observed in the VT group. Neuronal apoptosis was lower in all drug administration groups than in the VT group. Moreover, neuronal apoptosis was markedly lower in the high-dose group (rLj-RGD3 100.0 μg·kg-1) than in the other pretreatment groups.
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terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-endrLj-RGD 3 groupsNovel Recombinant Toxin Proteindose rLj-RGD 3 groupsTUNELrLj-RGD 3 proteinRT-PCRmRNA expression levelsRGD motif-containing peptidesintegrin-PI 3K anti-apoptosis pathwaysLampetra japonicaDalian Medical UniversityCerebral Reperfusion InjuryLampetra japonica fishPKBTTCBrain infarct volumesEDgene recombination technologyRGD-toxin protein Lj-RGD 3integrin-PI 3K pathwaymarine biotechnology drugsLampetra japonica RGD-peptideMethods rLj-RGD 3PI 3K protein kinase BEPischemiacaspase -3 expressionInstitutional Ethics CommitteerLj-RGD 3 actsBcl -2 proteinsDNA recombination techniquesSDrat stroke modelPI 3K pathwaysFAK24 hMCAOMiddle Cerebral Artery OcclusionVTIntegrin-PI 3K Pathway
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