Fig 2.tif (622.51 kB)
Neurological score and rota-rod measurements, 24-hours after permanent MCAO.
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posted on 2018-03-07, 18:54 authored by Diego Milani, Megan C. Bakeberg, Jane L. Cross, Vince W. Clark, Ryan S. Anderton, David J. Blacker, Neville W. Knuckey, Bruno P. MeloniA. Neurological grading scores (0 = no deficit, 5 = major deficit) for vehicle (saline), R18 and R18D (300 nmol/kg) treatment groups. Vertical lines on graph indicate the range and median for neurological score; n = 7–10. *p < 0.05, when compared to the vehicle. Note: one R18 treated animal inadvertently did not undergo neurological assessment. B. Rota-rod performance for vehicle, R18 and R18D treatment groups. Sec = seconds. Values are mean ± SD; n = 8–10.
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D-enantiomer R 18Dneuroprotective efficacySprague Dawley ratbEND .3 cellsneuroprotective propertiesWistar ratpoly-arginine peptide R 18artery occlusionR 18D24- hour exposureR 18novel neuroprotective agentinfarct volumepoly-arginine R 18MCAOHEKR 18 peptidepoly-arginine peptides24- hour peptide exposure duration0.058 vs 3
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