Neurological score and rota-rod measurements, 24-hours after permanent MCAO.
A. Neurological grading scores (0 = no deficit, 5 = major deficit) for vehicle (saline), R18 and R18D (300 nmol/kg) treatment groups. Vertical lines on graph indicate the range and median for neurological score; n = 7–10. *p < 0.05, when compared to the vehicle. Note: one R18 treated animal inadvertently did not undergo neurological assessment. B. Rota-rod performance for vehicle, R18 and R18D treatment groups. Sec = seconds. Values are mean ± SD; n = 8–10.