Module-level switches toggle each other to generate the cell cycle, locking <i>PI3K</i> oscillations to the rhythm of division.
2019-03-15T17:38:31Z (GMT) by
<p>Dynamics of regulatory molecule expression / activity during cell cycle entry from G0, showcasing the phase-locking of <i>PI3K</i> oscillations to the cell cycle. <i>X</i>-<i>axis</i>: time-steps; <i>y</i>-axis: nodes of the model organized in modules; <i>orange/blue</i>: ON/OFF; <i>white boxes & arrows</i>: first two peaks of <i>AKT1</i> activation with respect to DNA replication; <i>black dashed lines</i>: cytokinesis; <i>lime arrows</i>: first <i>AKT1</i>-high pulse in each division cycle.</p>
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