pgen.1008508.g008.tif (769.04 kB)
Model of MDT-15 and MED15 driven gene regulation in response to cadmium or high levels of zinc.
figure
posted on 2019-12-09, 18:31 authored by Naomi Shomer, Alexandre Zacharie Kadhim, Jennifer Margaret Grants, Xuanjin Cheng, Deema Alhusari, Forum Bhanshali, Amy Fong-Yuk Poon, Michelle Ying Ya Lee, Anik Muhuri, Jung In Park, James Shih, Dongyeop Lee, Seung-Jae V. Lee, Francis Christopher Lynn, Stefan Taubert[A] In the C. elegans intestinal cells, MDT-15 cooperates with HIZR-1 bound to the HZA element to induce the metal-sequestering metallothioneins (mtl-1 and -2) and the transporter cdf-2, which shuttles zinc into storage granules; excess cadmium is likely detoxified through similar mechanisms. ELT-2 may also contact Mediator to regulate cadmium or zinc responsive transcription. [B] In the mouse pancreatic β-cells, Med15 regulates the expression of genes such as Slc30a8/ZnT8 in response to elevated zinc levels, possibly via HNF4, or other, Mediator contacting transcription factors.
