Missense Mutation of POU Domain Class 3 Transcription Factor 3 in Pou3f3^L423P Mice Causes Reduced Nephron Number and Impaired Development of the Thick Ascending Limb of the Loop of Henle - Fig 8

Number of glomeruli per kidney and mean glomerular volumes in 12-day-old (A, C) and 60-week-old (B, D) Pou3f3^L423Pmutant mice and non-mutant control mice. The numbers of examined animals are given in parentheses. Data are means ± SD. Significant differences between homozygous and heterozygous mutants and non-mutant control mice are indicated by asterisks. *: p < 0.05, **: p < 0.01, ***: p < 0.001. Significant differences between male and female mice of identical genotypes are indicated by crosses. +: p < 0.05, ++: p < 0.01, +++: p < 0.001.