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Microglial distribution analysis using Iba-1 staining after Asm inhibition by amitriptyline for 2 weeks of recovery period after 5 weeks cuprizone feeding in the CCm.

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posted on 2017-06-05, 17:34 authored by Marwan Chami, Ramona Halmer, Laura Schnoeder, Katrin Anne Becker, Carola Meier, Klaus Fassbender, Erich Gulbins, Silke Walter

Iba-1+ cell numbers and iba-1 staining intensity in the CCm of amitriptyline- or control-treated animals showed no significance difference (b, c).

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    amyloid precursor proteinoligodendrocyte cell count12- week cuprizone treatmentenzyme acid sphingomyelinaseAcid sphingomyelinase deficiencywild-type C 57BL littermates2 weeks remyelinationacid sphingomyelinasedemyelinationcuprizone animal model2- week cuprizone withdrawal phasemyelin repairstudy glial reactionsclerosisDetrimental astroglial distribution

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