Fig 1.tif (520.29 kB)
Metal fractionation constant indicates that Cd is preferentially absorbed by synoviocytes.
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posted on 2017-07-25, 17:42 authored by Paola Bonaventura, Aline Lamboux, Francis Albarède, Pierre MiossecKD = (Me/70Zn) cells/(Me/70Zn) medium (where Me = metal) was calculated at 120h after addition of Cu, Cd, In, Pb, Au, Sn, Bi and ultra-trace amounts of 70Zn in cultures of OA or RA synoviocytes, treated (striped bars) or not (normal bars) with IL-17 and TNF-α. At equilibrium, KD = 1. Black lines represent the high affinity group, while white bars the low affinity group. Data are the mean of at least three independent experiments.
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anti-inflammatory effectsInterleukin -17Cd accumulationRAOAanti-proliferative effectsRegulatory effects-1XMT -1sgene expressionRheumatoid arthritisCell viabilitytissue inhibitorinductively-coupled-plasma mass-spectrometrycadmium-induced cytotoxicityCd-induced MT -1s expressionELISAmechanisms ZnResults SynoviocytesConclusion Zinc counteractssystem activationMMPZIP -8 expressiontumor necrosis factor-alphaCd anti-proliferativeZIP -8 importerintra-cellular contentTNFinflammation Objectives Zinc70 Zn spikemetal importIL -6 productionmetalloprotease -3
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