ppat.1008303.g001.tif (1.45 MB)
Maternal antibody passive transfer and functional activity in the neonate.
figure
posted on 2020-03-26, 17:26 authored by Stephanie N. Langel, Claire E. Otero, David R. Martinez, Sallie R. Permar(A) IgG passive transfer in the placenta influences FcγR-mediated cell cytotoxicity, phagocytosis, and complement activation in the developing fetus/newborn. (B) IgA passive transfer in the mammary gland results in FcαR- and IgA-mediated cell activation and microbiota regulation, respectively. Fab, antigen-binding fragment; Fc, crystallizable fragment; FcαR, Fc alpha receptor; FcRn, Fc receptor neonatal; FcγR, Fc gamma receptor; IgA, immunoglobulin A; IgG, immunoglobulin G; J-chain, joining chain; pIgR, polymeric immunoglobulin receptor.