Fig 9.TIF (1.8 MB)
Mapping of Elicited T Cell Responses to 11 Pools of Sequential Gag Peptides.
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posted on 2016-10-06, 17:34 authored by Melanie Thompson, Sonya L. Heath, Bentley Sweeton, Kathy Williams, Pamela Cunningham, Brandon F. Keele, Sharon Sen, Brent E. Palmer, Nicolas Chomont, Yongxian Xu, Rahul Basu, Michael S. Hellerstein, Suefen Kwa, Harriet L. RobinsonPanel A shows examples of the CD8+ and CD4+ responses in three participants. Panel B summarizes responses for the eight participants that completed the trial. 101–3 had a high background at TI allowing only dominant responses to be scored. Pre, responses present before vaccination; PV, responses scored after the 2nd MVA inoculation; TI, Responses scored at 2 weeks post the re-emergence of virus during treatment interruption. Red indicates responses present at baseline, post vaccination and either present or absent post TI, yellow indicates responses observed post vaccination and post treatment interruption, blue indicates responses scored only post vaccination and green indicates responses scored only during treatment interruption.
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8 weeks38 yearsGag selectionplasma HIVcontrol virusMedian agegrade 4 eventsInfected Participants2 MVAPhase 1 open-label trialtreatment interruption4 weeksantiretroviral therapy8 participantsvaccine-matched Gag peptidesdisplay signsvaccine-elicited T cell responsesTreatment InterruptionRNAre-emergenceGOVX-B6 monthsImmune Responsesvaccinationbaseline CD 4 countDNAGV-THantiretroviral treatment18 monthsAntiretroviral Therapypre-ART HIVre-emergent virusreactogenicity eventsElicited T cellsViral SuppressionTI9 participantsNCTstudy drug
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