Mapping Clinical Outcome Information to the Complement and Coagulation Pathway (See Attached File).

The Coagulation and Complement pathway is shown in this diagram, (source: https://www.wikipathways.org/index.php/Pathway:WP558.) Colored boxes represent results from random forest survival analyses. Gray boxes represent proteins associated with heart failure when the full sample was analyzed. Green boxes represent proteins that were associated with HF after analysis of the non-CKD sub-group. Yellow boxes represent proteins associated with HF after analysis of the CKD sub-group, including F7(Coagulation factor VII precursor), SERPINA1(Alpha-1-antitrypsin precursor), PROS1(Vitamin K dependent protein S precursor), PLAUR(Urokinase plasminogen activator surface receptor), KLKB1(Plasma kallikrein precursor), Complement(C)6, C7, C8-gamma chain, C9. Coagulation factors 3, 8, 12 and MASP2 were not measured.