pone.0202150.g005.tif (1.61 MB)
Lipid accumulation was not affected by deficiency of macrophage CD40.
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posted on 2018-08-10, 17:39 authored by Suzanne A. B. M. Aarts, Myrthe E. Reiche, Myrthe den Toom, Linda Beckers, Marion J. J. Gijbels, Norbert Gerdes, Menno P. J. de Winther, Esther Lutgens(A) Liver weight (n = 16 for HFD and n = 7 for SFD) (B) Quantification of oil-red-o stained area in the liver (n = 16 for HFD and n = 7 for SFD). (C) Liver TG levels (n = 6-9/group). (D) Liver total cholesterol levels (n = 6-9/group). (E) Representative pictures of ORO staining of the livers. (F) Histopathological score of liver steatosis (n = 16/group). (G). Plasma ALT levels (n = 7-9/group). (H). Plasma AST levels (n = 7-9/group). (I) mRNA expression of liver lipid metabolism genes (n = 7-10/group). Data is presented as mean ± SEM. N.D. means ‘not detectable’.
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adipose tissue leukocyte infiltrationWT40LMacrophage CD 40SFDadipose tissue inflammation40-CDameliorates adipose tissue inflammationinsulin resistanceHFDCD 40 flfl LysM creincreases insulin sensitivitymacrophage CD 40adipose tissue weightDIOplasma adiponectin levelstriglyceride levelsmacrophage CD 40. CD 40 flfl LysM cre miceadipose tissue cytokine levels
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