Fig 4.tif (718.16 kB)
Ligand-binding cavities and their corresponding thermal fluctuations.
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posted on 2017-12-14, 18:41 authored by Giuseppe Zanotti, Francesca Vallese, Alberto Ferrari, Ilaria Menozzi, Tadeo E. Saldaño, Paola Berto, Sebastian Fernandez-Alberti, Rodolfo BerniLigand cavities are defined according to (a) the 33 residues per subunit and (b) only the 10 buried residues, all listed in Table 4. The corresponding distributions of volumes, calculated for a large number of structures representing thermal distortions of the crystal structure of the wild type ligand-free TTR tetramer (PDB 1F41), are depicted as kernel density plots for the cavities either at the A-A’ or at B-B’ (bold) interfaces, respectively.
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multimeric proteinscrystal formscase studydynamics evidenceTTR tetramer dynamicscrystal stateTTR tetramersolutiondimer-dimer interfaceX-ray diffraction techniquesbinding sitestetrameric proteinT 4 binding sitesmodes analysisflexibilitytransthyretin tetramerthyroid hormone thyroxineligand cavitiescrystal structureD 2 symmetrybinding cooperativityhomotetrameric plasma transport protein87Mlatter propertyTTR scaffoldvibrational patterns
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