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JNK and Caspase-dependent ROS production reduces proliferation rates of adjacent cell populations.

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posted on 2019-08-19, 17:36 authored by Juan A. Sanchez, Duarte Mesquita, María C. Ingaramo, Federico Ariel, Marco Milán, Andrés Dekanty

(A-E) Wing discs carrying the gstD1-GFP reporter and expressing the indicated transgenes with ap-Gal4 were labeled to visualize GFP (green or grey) and myrTomato (red). RACS expression showed increased levels of gstD1-GFP in both the transgene-expressing and non-expressing domains (B-B’). Antioxidant treatment (C), co-expression of Puckered (puc; D) or p35 (E) fully rescued RA-induced gstD1-GFP levels. ap, apical; bs, basal. (F-H) BrdU and TUNEL assays in larval wing discs from individuals expressing GFP along with RACS or dmycRNAi under the control of en- or ci-Gal4 and cultured in a medium supplemented with antioxidants.

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