Intracellular dynamics under concomitant glucose and drug control.

(A) Concentration profiles of miR-451 (M) and mTOR (R) above the threshold values under concomitant infusions. (B) Trajectory of mTOR–miR-451–AMPK concentration profiles restrained in the proliferation region. (C) Dynamics of intracellular proteins, mass, and mass_s of the cell cycle model in response to concomitant glucose and drug infusions.