pgen.1007395.g001.tif (1.16 MB)
Identification and validation of pSNMs in 27 organ samples obtained from five individuals.
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posted on 2018-05-15, 17:37 authored by August Yue Huang, Xiaoxu Yang, Sheng Wang, Xianing Zheng, Qixi Wu, Adam Yongxin Ye, Liping Wei(A) Genomic landscape of the validated pSNMs. Circos plots from outer to inner represent individuals BBL1100C, BBL11121, BBLC1013, BBLD1005, and BBLD1010, respectively. The Y axis denotes the average minor allele fraction across pSNM-carrying organs of each donor. (B) Correlation of the allele fractions estimated by whole-genome sequencing and targeted ultra-deep resequencing (PASM) of the validated sites. The shape, color, and size of the dots represent the donor and organ type carrying the pSNMs and the site-specific depth of whole-genome sequencing.
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Distinctive typesreplication timinglate-replicating regionsclonal expansion eventsmutation rateCpG sitesclonal expansion pSNMswhole-genome sequencingpostzygotic mosaicism27 postmortem organ samplesallele fractionsorgans Postzygotic single-nucleotide mosaicismschromatin statesultra-deep amplicon re-sequencingintra-organ comparisonpostzygotic single-nucleotide mosaicisms164 pSNMs
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