Figure_9.tif (1.71 MB)

Homology modelling of the ρ-Da1a binding site in the α_1A-AR and the MT7 toxin.

figure

posted on 2013-07-25, 01:49 authored by Arhamatoulaye Maïga, Jon Merlin, Elodie Marcon, Céline Rouget, Maud Larregola, Bernard Gilquin, Carole Fruchart-Gaillard, Evelyne Lajeunesse, Charles Marchetti, Alain Lorphelin, Laurent Bellanger, Roger J. Summers, Dana S. Hutchinson, Bronwyn A. Evans, Denis Servent, Nicolas Gilles

Views from the side of the TM bundle (Panel A), and from the top of the extracellular space (Panel B). F187^5.41, F193^5.47, F281^6.44, M292^6.55, F308^7.35 in green. D106^3.32 and the double S188^5.42/S192^5.46 in orange. F86^2.64, F288^6.51 and F312^7.39 in red. Panel C :3D structure of the three-finger fold MT7 toxin (2vlw) with the four conserved disulfide bridges in red.