Histological scores at D42 intradermal challenge sites.

<p>Data are presented as histological scores at termination, following day 42 p.i. intradermal challenge, grouped by route of sensitization with <i>C</i>. <i>burnetii</i> Nine Mile (<i>Cb</i>9M) (i.p., intraperitoneal; i.n., intranasal) or saline controls. Scores are shown for injection sites harvested at day 7 p.c. (open shapes) and day 21 p.c. (filled shapes). Values are presented by challenge dose (A) 0 μg Coxevac, (B) 1 μg Coxevac, (C) 2 μg Coxevac, and (D) 4 μg Coxevac. <sup>1</sup>Histopathological scoring (0–5) is as noted in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0205882#pone.0205882.t001" target="_blank">Table 1</a>. Error bars represent group mean and standard deviations. Group mean differences assessed by one-way ANOVA with Tukey’s multiple correction test; *P≤0.05; ** P≤0.01.</p>