Histologic changes of collagen fibers after high-intensity focused ultrasound (HIFU) irradiation at the silicone injection site.

The first row depicts the results of Masson’s trichrome (MT) staining (×100) and the second row depicts the results of Sirius Red staining (×100). Compared with the control group, the experimental group (HIFU treated) had thicker fibrous capsules and more dense, irregular, and disorganized collagen fibers.