HSV-1 infects human NK cells.

(A) PBMCs were cultured with mock infected inoculum or inoculum infected with HSV-1 expressing GFP under different viral promoters (ICP47, ICP6 or gB as specified) for 1 day. Infection of NK cells (viable CD3^–CD56⁺ cells) was determined by flow cytometry detection of GFP. (B) Frequency of NK cell infection with HSV-1 GFP-pICP47 performed as in (A), for seven donors. Symbols represent individual donors, and bar indicates mean.