pone.0175223.s001.pdf (345.69 kB)
Selected copy number plots for chromosomes 6 and 17.
journal contribution
posted on 2017-04-19, 17:39 authored by Verena Tiran, Stefanie Stanzer, Ellen Heitzer, Michael Meilinger, Christopher Rossmann, Sigurd Lax, Oleksiy Tsybrovskyy, Nadia Dandachi, Marija BalicDepicted are segmented log2-ratio plots chromosome 6 and 17. The X- and Y-axes indicate the chromosome and the log2-ratios, respectively. Primary tumor, the unsorted primary cells, and the CD44-positive cells show very consistent copy number profiles. The high level gains on the long arm of chromosomes 6 and 17, respectively can also be observed in the ALDH-positive cell fraction, although with a much lower amplitude indicating a lower amount of tumor cells.
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genome sequencingstage breast cancer diseasetumor subpopulationsmetastatic spread17 metastatic breast cancer patientsform spheresCD 44sequencing methodtumor sitetumor cellsunsorted cellscopy number profilesDNA copy number profilesbreast cancerPleural effusionscopy number analysiseffusion aspiratesterm cell culturecell subpopulations ALDH 1Patient-derived aspiratesMalignant cellsbone metastasisnon-CSC subpopulationsCSC subpopulationseffusion sample
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