pgen.1007711.g002.tif (9.9 MB)
Gata4 is required in Hh-receiving cells for OFT development.
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posted on 2019-05-23, 17:29 authored by Jielin Liu, Henghui Cheng, Menglan Xiang, Lun Zhou, Bingruo Wu, Ivan P. Moskowitz, Ke Zhang, Linglin Xie(A-K’) Histology of Gata4 transgenic mouse embryonic heart at E14.5. The lower panels (A’-C’) and upper panels (D-K) showed that the opening of the AO connected to the right ventricle in the Gata4 haploinsufficency, while in control embryos the AO opened to the left ventricle. LV, left ventricle; RV, right ventricle; ao, aorta artery; pt, pulmonary trunk. Magnification: 40X (L-M) Blue ink stained embryo heart at E14.5. LV, left ventricle; RV, right ventricle; ao, aorta artery, pt, pulmonary trunk. Red arrow indicates the ink injected direction.
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DORVcardiogenic transcription factorTFGata 4 regulationGata 4 haploinsufficiencyPTAcause outflow tractGata 4Restored cell proliferationOFT defectsrescue OFT defectsrenormalized SHF cell proliferationEMTSHF Hh-receiving cellsoutlet right ventricleluciferase reporter assayGata 4 heterozygotesGata 6 expressionoutflow tract developmentOFT developmentVSD
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