GSA power simulation over four different moderately sparse configurations of gene signal density.

<p>Simulated power of MAGMA, GSEA, SKAT, GHC, and GBJ (all self-contained versions) with random sets of ten genes selected from 10,000 total genes. From the ten genes in the set, <i>a</i> genes are selected to hold <i>b</i> causal SNPs each. The four subfigures correspond to (A) <i>a</i> = 1, <i>b</i> = 4, (B) <i>a</i> = 4, <i>b</i> = 1, (C) <i>a</i> = 4, <i>b</i> = 2, (D) <i>a</i> = 8, <i>b</i> = 1. The effect size is given on the x-axis. We perform 100 simulations at each parameter setting and test at <i>α</i> = 0.01. The relative power of each test is affected by both the signal configuration and signal sparsity.</p>