pone.0200908.g002.tif (941.17 kB)
Fasting serum bile acid profile.
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posted on 2018-07-30, 17:31 authored by Karolina E. Zaborska, Seon A. Lee, Darline Garribay, Eumee Cha, Bethany P. CummingsTotal bile acid concentration (A), 12αOH:non-12αOH ratio (B) and hydrophobicity index (C) in fasting serum samples. Relative proportions of bile acid subtypes in fasting serum samples from HFD (D) and DCA treated (E) mice. Data are expressed as mean ± SEM, **P<0.01, ****P<0.0001 by Student’s t-test, n = 6 per group. TCA, taurocholic acid; TLCA, taurolitocholic acid; HDCA, hyodeoxycholic acid; GUDCA, glycoursodeoxycholic acid; CDCA, chenodeoxycholic acid; UDCA, ursodeoxycholic acid; αω MCA, αω muricholic acid; βMCA, β-muricholic acid and Tαβ MCA, tauro-αβ muricholic acid.
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hepatic ER homeostasisC 57BL micemice Bile acidsER stressattenuate hepatic endoplasmic reticulumDCADeoxycholic acid supplementation impairs glucose homeostasisbile acid subtypebody glucose regulationhepatic insulinglucose regulationbile acid subtypesbody glucose homeostasisinsulin tolerance testingbile acid profilehepatic ER stress
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