Fasting serum bile acid profile.

Total bile acid concentration (A), 12αOH:non-12αOH ratio (B) and hydrophobicity index (C) in fasting serum samples. Relative proportions of bile acid subtypes in fasting serum samples from HFD (D) and DCA treated (E) mice. Data are expressed as mean ± SEM, **P<0.01, ****P<0.0001 by Student’s t-test, n = 6 per group. TCA, taurocholic acid; TLCA, taurolitocholic acid; HDCA, hyodeoxycholic acid; GUDCA, glycoursodeoxycholic acid; CDCA, chenodeoxycholic acid; UDCA, ursodeoxycholic acid; αω MCA, αω muricholic acid; βMCA, β-muricholic acid and Tαβ MCA, tauro-αβ muricholic acid.