pgen.1008335.g003.tif (461.96 kB)
Effects of telomere end-to-end fusion and telomere tethering to the nuclear envelope on GCR formation.
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posted on 2019-08-27, 17:37 authored by Hiroyuki Irie, Io Yamamoto, Yusuke Tarumoto, Sanki Tashiro, Kurt W. Runge, Fuyuki Ishikawa(A) GCR rates of wild-type, taz1Δ, and rap1Δ strains in the presence or absence of lig4+. (B) GCR rates of strains with INM protein mutants. GFP-Bqt4ΔN or Rap1-GFP-Bqt4ΔN fusion protein was expressed from the bqt4 promoter integrated into genomic DNA as described previously [23]. (C) GCR rates of wild-type, taz1Δ, and rap1Δ strains in the presence or absence of bqt4+. Asterisks represent significant differences (P < 0.05) from the wild-type strain unless otherwise noted. P-values were obtained by the two-tailed Mann–Whitney test.
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GCR ratesRAP 1 homologueschromosomal rearrangementsfission yeast Genomic rearrangementstelomere length homeostasisshelterin components Taz 1I-SceI-mediated DSB-induction experimentsTRFTelomere-binding proteins Taz 1Poz 1-binding domaincause cell deathchromosomefission yeast cellsshelterin-mediated telomere functionsRap 1DSB repair
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