Fig 7.tif (295.92 kB)
Effects of metabolic inhibitors on cellular ATP:ADP ratio.
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posted on 2017-05-19, 17:36 authored by Mingming Yang, Amy E. Chadwick, Caroline Dart, Tomoko Kamishima, John M. QuayleEffect of metabolic inhibitors on cellular ATP:ADP ratio measured after 15 min in the absence and presence of, left to right, DMSO (NS), 5 mM 2-DG (p<0.01), 1 μM rotenone (p<0.01), 1 μM antimycin (p<0.05), 6 μM oligomycin (p<0.001) and 1 μM CCCP (p<0.05). Statistical analysis was performed using Student’s un-paired t test (n = 4).
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Intracellular ATP leveloxidative phosphorylationarterymitochondrial oxidative phosphorylationdemand causes vasodilationintracellular ATP levelglycolysis reserve capacityreserve capacityintracellular ATP concentrationMetabolic intervention influencesmuscle cellsglycolysis stress testsbioenergetic profile
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