Effects of ACO on sodium currents in Guinea-pig ventricular myocytes.

(A) Representative traces of the peak I_Na recorded in a Guinea-pig ventricular myocyte prior to and after 3 μM ACO. (B) The I-V curves showing the current densities of peak I_Na. n = 5. (C) The SS-inactivation and -activation curves. n = 5. (D) The I-V curves of the voltage-gated I_NaL densities. n = 5. (E) Representative traces of voltage-dependent I_NaL recorded in a Guinea-pig ventricular myocyte prior to and post 3μM ACO. *p < 0.05, ^†p < 0.01, vs. baseline.