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Effect of various metabolic inhibitors on isoprenaline stimulated I_Ca,L.

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posted on 2017-08-31, 17:49 authored by Giedrius Kanaporis, Rimantas Treinys, Rodolphe Fischmeister, Jonas Jurevičius

Peak amplitude of ISO-stimulated I_Ca,L during exposure of the cells to various inhibitors of oxidative phosphorylation. Values are presented as means ± SEM for the number of cells indicated in parentheses. * P<0.05 vs. ISO alone.

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Metabolic inhibition intracellular acidosis mitochondrial F 1 F 0 ATP hydrolysis Metabolic stress intracellular pH buffering capacity LTCC F 1 F 0 non-hydrolysable ATP analogue AMP-PCP FCCP ATP-synthase 3 mM intracellular ATP

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Effect of various metabolic inhibitors on isoprenaline stimulated ICa,L.