Table 1.xls (5.5 kB)
EC50s of the C5-substituted 2,4-DAQs on SMN2-drived BLA activity.
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posted on 2017-06-29, 18:21 authored by Cinsley Gentillon, Andrew J. Connell, Ryan W. Kirk, Matthew E. R. ButchbachEC50s of the C5-substituted 2,4-DAQs on SMN2-drived BLA activity.
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increase Atoh 7 mRNA expressionRGSMN 2 gene regulationSMN 2 promoterameliorate disease severitySMN 2DRNT 1compounds increase SMN protein levelsATOH 7 mRNA levelsSMN 2 promoter-driven reporter gene activitySMA fibroblastsDRTN 2 transcript levelsSMN 2 inducertype II SMA fibroblastsincrease SMN 2 mRNA levelsDAQincrease ATOH 7ATOH 7 levelsNSC -34 cellsDRNT 2 transcript levels
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