Fig 2.tif (1.04 MB)
Cytoprotective effects of ginsenosides.
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posted on 2017-08-16, 17:30 authored by Carlos Fernández-Moriano, Elena González-Burgos, Irene Iglesias, Rafael Lozano, M. Pilar Gómez-Serranillos(A) Cytoprotective effects of six ginsenosides in SH-SY5Y cell line against rotenone-mediated toxicity (range of concentrations: 0.5–10 μM), assessed by MTT reduction assay. Cells were pre-treated with ginsenosides for 24 h and then exposed to rotenone 50 μM for other 24 h. The viability of control cells was normalized to 100%. Means ± SD, * p < 0.05 Vs control, # p < 0.05 Vs rotenone. (B) Representative images of the morphological studies conducted on SH-SY5Y cell model with ginsenosides Rb1 and Rg1.
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Nrf 2 pathway activationBcl -2 expressionsSH-SY 5Y cellsameliorated redox statusMethods Oxidative stressROSginsenosides Rb 1lipid peroxidation levelsmitochondrialapoptotic cell deathcalcium homeostasis disruptionSOD activitymodel Background GinsengMMPRg 1 exhibit neuroprotectiveblood brain barrieroxidative stress-mediated neurotoxicityRg 1TBARSNrf 2 activationPoor BBB permeation
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