Conceptual diagram of the effects of antalarmin in the adrenal gland.

It is known that both CRH receptors are strongly expressed in the medulla of the adrenal gland, which is responsible for the secretion of catecholamines (epinephrine and norepinephrine). A: While CRHR1 activation enhances catecholamine release, CRHR2 activation decreases its release. By blocking the CRHR1 receptor with antalarmin for a short period during the initiation of endometriosis, we hypothesize that a decrease in catecholamine release occurs. B: When antalarmin was no longer present, there was a reactive increase in CRHR1. However, to counterbalance the increase in CRHR1 activity, we believe that CRHR2 was also upregulated to maintain an appropriate release of catecholamines. CRH: corticotrophin releasing hormone, Epi: epinephrine, NorEpi: norepinephrine. Created with BioRender.com. Figure was exported under a paid subscription.