Comparison of methods of modeling variability.
Modeling of cell-to-cell conductance variation and inter-monolayer conductance variation alone, or in combination (“dual variation”) is not sufficient to match all experimental variability. The addition of inter-monolayer bulk conductivity variation (“triple variation”) allowed for the replication of experimentally observed variability in single cells (A and B), as well as in macroscopic conduction velocity (C). Box plots to the left of each histogram indicate mean +/- one standard deviation. Asterisks indicate that variances are significantly different (p < 0.05) from experimental variability, using Levene’s test for equal variances.