Comparison of gene expression in m skin samples with psoriasis lesions to m healthy skin samples.

Statistic maxR is estimated with 103 draws of two data sets of size 2m from GSE30999. Differences between average ranks of pathway members by WAP and DEG are estimated for 103 data sets of size 2m randomly drawn from GSE30999. Confidence Intervals (CI, 95%, bootstrapping with 106 trials, vertical lines) are estimated for average maxR values (dots) based on WAP scores, DEG scores (A), their differences (B) and average difference between pathway member ranks based on DEG and WAP scores (C). Color and labels represent the following Reactome pathways—IFNA (green): Regulation of IFNA signaling, NFkB (magenta): TNFR1-induced NFkappaB signaling pathway, TNF (dark blue): TNF signaling, TNFR1 (light blue): Regulation of TNFR1 signaling, IFNG (teal): Regulation of IFNG signaling, IL-17 (yellow): Interleukin-17 signaling, IL-12 (red): Interleukin-12 family signaling.