Comparison of expression of elt-2-regulated genes during development and aging.

For each class of elt-2-regulated genes(general intestinal function, intestinal establishment and adult function), the heatmaps show how the genes are expressed during development and aging. Only genes profiled in all three experiments are shown. (A-C) General intestinal genes. (A) Heatmap shows expression changes of the general intestinal genes during development using RNA-seq data from Gerstein et al., 2014. Values are Log₂ expression fold changes during normal development relative to early embryos. Timepoints are early embryo (EE), late embryo (LE), L1, L2, L3, L4, and Day 1 of adulthood. (B) Heatmap showing expression of the general intestinal genes of ELT-2 during aging, using DNA microarray data from Budovskaya et al. 2008. Values are Log₂ expression fold changes during aging relative to Day 2. Timepoints are Days 2, 5, 8, and 11 of adulthood. (C) Heatmaps showing expression of the general intestinal genes following elt-2 RNAi in the L1 and L4 larval stages. Values are log₂ fold change in elt-2 RNAi compared to control RNAi. (D-F) Intestinal establishment genes. Similar to (A-C). (G-I) Adult function genes. Similar to (A-C).